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Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines

Year: 2019

Type: article

Abstract: With increasing emphasis on precision approaches to therapeutics, product development has shifted focus to a genome-guided approach to develop novel therapeutics.This Commentary highlights the evolution of next generation precision medicines.We briefly summarize the current state of the science and what lies ahead in terms of opportunities and challenges for development of innovative therapeutic modalities such as antisense oligonucleotides (ASOs) and clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (Cas 9)-based therapies.PHARMACOGENETICS www.cts-journal.comPast, Present, and Future of Precision Medicines Ramamoorthy et al.

Source: Clinical and Translational Science

DOI: 10.1111/cts.12675

Authors: Anuradha Ramamoorthy, Jason H. Karnes, Richard Finkel, Rebecca Blanchard, Michael Pacanowski

Institutions: United States Food and Drug Administration, Center for Drug Evaluation and Research, University of Arizona, Nemours Children's Clinic

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000