Work

The PHD finger of Spp1 mediates histone modification cross-talk

Year: 2019

Type: article

Abstract: Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [Biochem. J.476, 1957–1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in the Saccharomyces pombe and mammalian orthologues of Spp1.

Source: Biochemical Journal

DOI: 10.1042/bcj20190492

Authors: Catherine A. Musselman, Tatiana G. Kutateladze

Institutions: University of Colorado Anschutz, University of Colorado Denver

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G7241820863