Work

STAT3, a Master Regulator of Anti-Tumor Immune Response

Year: 2019

Type: review

Abstract: Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer progression is dependent on the activation or repression of transcription programs involved in the proliferation/activation of lymphoid and myeloid cells. One of the main transcription factors involved in many of these pathways is the signal transducer and activator of transcription 3 (STAT3). In this review we will focus on the role of STAT3 and its regulation, e.g. by phosphorylation or acetylation in immune cells and how it might impact immune cell function and tumor progression. Moreover, we will review the ability of STAT3 to regulate checkpoint inhibitors.

Source: Cancers

DOI: 10.3390/cancers11091280

Authors: Cédric Rébé, François Ghiringhelli

Institutions: Inserm, Centre Georges François Leclerc, Centre de recherche Translationnelle en Médecine moléculaire

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,824