Biological Characterization of Conserved Residues within the Cytoplasmic Tail of the Pichinde Arenaviral Glycoprotein Subunit 2 (GP2)
Year: 2019
Type: article
Abstract: Several arenaviruses, such as Lassa virus (LASV), can cause severe and lethal hemorrhagic fever diseases with high mortality and morbidity, for which no FDA-approved vaccines or therapeutics are available. Viral entry is mediated by the arenavirus GP complex, which consists of the stable signal peptide (SSP), the receptor-binding subunit GP1, and the transmembrane subunit GP2. The cytoplasmic tail (CT) of GP2 is highly conserved among arenaviruses, but its functional role in viral replication is not completely understood. Using a reverse genetics system of a prototypic arenavirus, Pichinde virus (PICV), we show that the GP2 CT contains certain conserved residues that are essential for virus replication, implicating it as a potentially good target for developing antivirals and live-attenuated viral vaccines against deadly arenavirus pathogens.
Source: Journal of Virology
DOI: 10.1128/jvi.01277-19
Institution: University of Minnesota
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mechanism of Lassa fever virus Z protein in immune suppression and viral virulence, Novel Mechanism of Immune Evasion by Arenaviral Nucleoproteins, G2484305438, G3893966638, Training in PharmacoNeuroImmune Substance Abuse Research, G6646030129, Molecular determinants of virulent arenavirus infection in hosts
OpenAlex ID: W2970530821