Year: 2019
Type: dissertation
Abstract: Utilizing paper as an easy-to-use and disposable platform for micro analytical devices has garnered considerable attention for point-of-care applications in clinical diagnostics.Moreover, multiplexing these devices enables simultaneous execution of multiple assays on a single device without cross-contamination.Urine analysis has been used for various diagnostics, including, but not limited to, urinary tract infection (UTI), kidney function, diabetes, pregnancy, and hydration testing.A normal sample of urine consists of several elements: urea, chloride, sodium, amino acids, sulphate, phosphate, potassium, and other trace chemicals, as well as various biomolecules.Abnormal levels of these substances, atypical urine chemical properties, or the presence of certain other chemicals or molecules can be used to diagnose certain health conditions.According to the World Health Organization (WHO), the most effective way to increase access to medical diagnostics in developing countries is to provide these communities with tools for accessible and affordable local production.In response to this need, in my PhD research, I focused on design and high-throughput fabrication of paper-based microanalytical devices with fast, simple, and cost-effective methods for urinalysis.For patterning the hydrophobic barriers and high-throughput fabrication of paper-based microfluidics, novel fabrication methods were proposed along with compatible detection methods including colorimetric, electrochemical and fluorescent.First, a pen-plotterbased approach was developed integrated with a custom-made, low-cost paper feeder.Fariba Ghaderinezhad University of Connecticut,
Author: Fariba Ghaderinezhad
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2970605071