Work

The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils

Year: 2019

Type: article

Abstract: Periodontal disease is a significant health burden, causing tooth loss and poor oral and overall systemic health. Dysbiosis of the oral biofilm and a dysfunctional immune response drive chronic inflammation, causing destruction of soft tissue and alveolar bone supporting the teeth. Treponema denticola , a spirochete abundant in the plaque biofilm of patients with severe periodontal disease, perturbs neutrophil function by modulating appropriate phosphoinositide (PIP) signaling.

Source: Infection and Immunity

DOI: 10.1128/iai.00553-19

Authors: Megan M. Jones, Stephen T. Vanyo, Michelle B. Visser

Institution: University at Buffalo, State University of New York

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Dental and Craniofacial Research