Work

Immunotherapeutic Challenges for Pediatric Cancers

Year: 2019

Type: article

Abstract: Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers share some similarities related to microenvironmental changes, pediatric cancers are unique, and adult cancer practices may not be wholly applicable to our pediatric patients. This review highlights the differences in tumorigenesis, viral infection, and immunologic response between children and adults that need to be considered when trying to apply experiences from experimental therapies in adult cancer patients to pediatric cancers.

Source: Molecular Therapy — Oncolytics

DOI: 10.1016/j.omto.2019.08.005

Authors: Brian Hutzen, Mohammed Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady

Institutions: Abigail Wexner Research Institute, The Ohio State University, New York Medical College

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500

Funders: U.S. Department of Defense, American Cancer Society, Alex's Lemonade Stand Foundation for Childhood Cancer, CancerFree KIDS, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G1442899210, Tumor-mediated metabolic modulation of regulatory T cells, G180321955, G3164291660, G3522905636, G4297338006, G5225000690, Oncogenic fusion gene FAX-FKHR in driving metabolic reprogramming in alveolar rhabdomyosarcoma, Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers, Pediatric Ohio-New York Cancer (Peds-ONC) Immunotherapy Center, G8291647282, Dissect and target Arginine-polyamine metabolic axis in T cell mediated inflammation and autoimmunity

OpenAlex ID: W2970664994

FWCI: 1.904

Cites: 171

Cited by: 34

Related to: 10