Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model
Year: 2019
Type: article
Abstract: The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbated amyloid-beta (Aβ) retention, neuroinflammation and cognitive decline. Therefore, preserving metabolic function early on may be critical to reducing the risk for AD. Here, we show that inulin increases beneficial microbiota and decreases harmful microbiota in the feces of young, asymptomatic APOE4 transgenic (E4FAD) mice and enhances metabolism in the cecum, periphery and brain, as demonstrated by increases in the levels of SCFAs, tryptophan-derived metabolites, bile acids, glycolytic metabolites and scyllo-inositol. We show that inulin also reduces inflammatory gene expression in the hippocampus. This knowledge can be utilized to design early precision nutrition intervention strategies that use a prebiotic diet to enhance systemic metabolism and may be useful for reducing AD risk in asymptomatic APOE4 carriers.
Source: PLoS ONE
Authors: Jared D. Hoffman, Lucille M. Yanckello, George Chlipala, Tyler C. Hammond, Scott D. McCulloch, Ishita Parikh, Sydney Sun, Josh M. Morganti, Stefan J. Green, Ai-Ling Lin
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,595
Funders: American Federation for Aging Research, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: Supplement to Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model, A High-Field Small Animal MR Imager for Biomedical Research, G2134844890, Pharmacology and Nutritional Sciences: Multidisciplinary Approaches for Metabolic Disease, G4118999032, G4790621666, Dystrophic functions of aged astrocytes following traumatic brain injury, Multi-Modal MRI to Assess Alzheimer's Disease Prevention in an APOE4 MouseModel, Kentucky Center for Clinical and Translational Science
OpenAlex ID: W2970871002