Work

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

Year: 2019

Type: review

Abstract: Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.

Source: Cells

DOI: 10.3390/cells8090991

Authors: Jordi Gonzalez-Molina, Silvia Gramolelli, Zehuan Liao, Joseph W. Carlson, Päivi M. Ojala, Kaisa Lehti

Institutions: Karolinska Institutet, University of Helsinki, Nanyang Technological University, Imperial College London

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,824