Year: 2019
Type: article
Study design: Observational Study
Abstract: The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure, and reproduction. Here, we show that anorexia nervosa (AN) patients, contrary to normal weight and constitutionally lean individuals, respond with a paradoxical reduction in hypothalamic levels of glutamate/glutamine (Glx) upon feeding. This reversal of the Glx response is associated with decreased wiring in the arcuate nucleus and increased connectivity in the lateral hypothalamic area, which are involved in the regulation on a variety of physiological and behavioral functions including the control of food intake and energy balance. The identification of distinct hypothalamic neurochemical dysfunctions and associated structural variations in AN paves the way for the development of new diagnostic and treatment strategies in conditions associated with abnormal body mass index and a maladaptive response to negative energy balance.
Source: Neuroendocrinology
DOI: 10.1159/000503147
Institutions: Inserm, Université de Lille, University of Southern California, Children's Hospital Los Angeles, Centre Hospitalier Universitaire de Lille, Saban Research Institute, Centre Hospitalier Universitaire de Saint-Pierre, Assistance Publique – Hôpitaux de Paris, NeuroDiderot, Groupe Hospitalier de l'Institut Catholique de Lille, Karolinska Institutet, European Genomic Institute for Diabetes, Recherche translationnelle sur le diabète et les troubles métaboliques
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
Funders: Brain and Behavior Research Foundation, National Alliance for Research on Schizophrenia and Depression, Université de Lille, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, H. Lundbeck A/S, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W2971575234