Year: 2016
Type: article
Abstract: A large contributor to cellular aging is the decline in mitochondrial fitness. The mitochondrial oxidative phosphorylation pathway is responsible for producing adenosine triphosphate (ATP) and reactive oxygen species (ROS) within eukaryotic cells. Using NIH/3T3 mouse embryonic fibroblasts and H2O2 as a model of oxidative stress senescence-induced aging, it was found low levels of oxidative stress mimicked senesced traits, weakened mitochondrial and cellular membranes, and decreased levels of cellular ROS and ATP. By understanding the consequences of oxidative stress on mitochondria, insight may be gained for future studies and developments towards a reliable model of aging using more than H2O2 as oxidative stressors to replicate cellular aging, as more experimentation is needed.
Source: Digital WPI
Author: Sunny Sang Huynh Nguyen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2971575337