Work

5-FU induced cardiotoxicity: case series and review of the literature

Year: 2019

Type: review

Abstract: BACKGROUND: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. CONCLUSION: Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible.

Source: Cardio-Oncology

DOI: 10.1186/s40959-019-0048-3

Authors: Cai Yuan, Hiral Parekh, Carmen Allegra, Thomas J. George, Jason S. Starr

Institutions: University of Florida Health, University of Florida, UF Health Cancer Center, Mayo Clinic in Florida

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,380