Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer
Year: 2019
Type: article
Study design: Observational Study
Abstract: Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62–1.06). Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.
Authors: Julia Butt, Mazda Jenab, Michael Pawlita, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Franck Carbonnel, Francesca Romana Mancini, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Domenico Palli, Valeria Maria Pala, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Bas Bueno-de-Mesquita, Carla H. van Gils, Roel C.H. Vermeulen, Elisabete Weiderpass, José Ramón Quirós, Eric Jeffrey Duell, Maria-Jose Sánchez, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Bethany Van Guelpen, Sophia Harlid, Aurora Perez-Cornago, Marc J. Gunter, Neil Murphy, Heinz Freisling, Dagfinn Aune, Tim Waterboer, David J. Hughes
Institutions: German Cancer Research Center, Heidelberg University, Centre international de recherche sur le cancer, Aarhus University Hospital, Danish Cancer Society, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Assistance Publique – Hôpitaux de Paris, Bicêtre Hospital, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, University General Hospital Attikon, Fondazione IRCCS Istituto Nazionale dei Tumori, Piedmont Reference Center for Epidemiology and Cancer Prevention, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Imperial College London, Utrecht University, University of Helsinki, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Biogipuzkoa Health Research Institute, Instituto Murciano de Investigación Biosanitaria, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Umeå University, University of Oxford, University College Dublin
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2971782270