Work

Modular Approach to Degradable Acetal Polymers Using Cascade Enyne Metathesis Polymerization

Year: 2019

Type: article

Abstract: A modular synthetic approach to degradable metathesis polymers is presented using acetal-containing enyne monomers. The monomers are prepared in a short and divergent synthetic sequence that features two points of modification to tune polymerization behavior and introduce molecular cargo. Steric and stereochemical elements are critical in the monomer design in order to provide rapid and living polymerizations capable of generating block polymers. The developed polyacetal materials readily undergo pH-dependent degradation in aqueous mixtures, and the rate of hydrolysis can be tuned through post-polymerization modification with triazolinedione click chemistry. This presents a new scaffold for responsive metathesis polymers that may find use in applications that requires controllable breakdown and release of small molecules.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201909172

Authors: Liangbing Fu, Xuelin Sui, Alex E. Crolais, Will R. Gutekunst

Institution: Georgia Institute of Technology

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences