Work

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

Year: 2019

Type: article

Abstract: led to diminished binding and activation of XCR1 by XCL1. These findings demonstrate the utility of a hybrid approach, using biological data and homology modeling, to study chemokine-GPCR interactions.

Source: Science Signaling

DOI: 10.1126/scisignal.aat4128

Authors: Jamie C. Fox, Monica A. Thomas, Acacia F. Dishman, Olav Larsen, Takashi Nakayama, Osamu Yoshie, Mette Marie Rosenkilde, Brian F. Volkman

Institutions: Medical College of Wisconsin, University of Copenhagen, Kindai University

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Hørslev-Fonden, Ministry of Education, Culture, Sports, Science and Technology, Carlsbergfondet, Lundbeckfonden, Novo Nordisk, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Structural Basis for Chemokine Function, G106377354, G352720048, G5419123091, G5926885969, G6997113705, G8883367568, G9000137617, G9000154298, G9000185818, G9000204919, G9000215711, G9000232373, G9000338021

OpenAlex ID: W2971995469

FWCI: 1.27

Cites: 89

Cited by: 25

Related to: 10