Year: 2019
Type: article
Abstract: Figure 1.TLR8 signaling enhances anti-tumor immunity and immunotherapy.Treg cells and tumor cells have accelerated glucose metabolism and induce senescence and suppression in effector T cells during their cross-talks.TLR8 signaling inhibits glucose metabolism in Treg cells and decreases tumor-produced cAMP, resulting in reversal of responder T cell senescence and enhanced anti-tumor immune responses.
Source: Aging
Authors: Xia Liu, Lingyun Li, Guangyong Peng
Institution: Saint Louis University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2972128248