Work

Radical α-C–H Cyclobutylation of Aniline Derivatives

Year: 2019

Type: article

Abstract: A catalytic system has been developed for the direct alkylation of α-C–H bonds of aniline derivatives with strained C–C σ-bonds. This method operates through a photoredox mechanism in which oxidative formation of aminoalkyl radical intermediates enables addition to a bicyclobutane derivative, giving rise to α-cyclobutyl N-alkylaniline products. This mild system proceeds through a redox- and proton-neutral mechanism and is operational for a range of substituted arylamine derivatives.

Source: Synlett

DOI: 10.1055/s-0039-1690197

Authors: Cameron J. Pratt, R. Adam Aycock, Max D. King, Nathan T. Jui

Institution: Emory University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G3094633945, Novel Radical Reactions for C-C Bond Formation