Work

VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6

Year: 2019

Type: article

Abstract: VSTM2A is a novel antagonist of canonical Wnt signaling by directly binding to LRP6 and induces LRP6 endocytosis and degradation. VSTM2A is a potential prognostic biomarker for the outcome of CRC patients.

Source: Theranostics

DOI: 10.7150/thno.34989

Authors: Yujuan Dong, Yanquan Zhang, Wei Kang, Guoping Wang, Huarong Chen, Akira Higashimori, Geicho Nakatsu, Minnie Go, Joanna HM Tong, Shu Zheng, Ka Fai To, Joseph JY Sung, Xiaoyong Yang, Simon SM Ng, Jun Yu

Institutions: Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Osaka City University, The University of Osaka, Zhejiang University, Yale University

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W2972603130

FWCI: 1.902

Cites: 20

Cited by: 35

Related to: 10