Work

Non-Genetic Factors in Schizophrenia

Year: 2019

Type: article

Abstract: PURPOSE OF REVIEW: We review recent developments on risk factors in schizophrenia. RECENT FINDINGS: The way we think about schizophrenia today is profoundly different from the way this illness was seen in the twentieth century. We now know that the etiology of schizophrenia is multifactorial and reflects an interaction between genetic vulnerability and environmental contributors. Environmental risk factors such as pregnancy and birth complications, childhood trauma, migration, social isolation, urbanicity, and substance abuse, alone and in combination, acting at a number of levels over time, influence the individual's likelihood to develop the disorder. Environmental risk factors together with the identification of a polygenic risk score for schizophrenia, research on gene-environment interaction and environment-environment interaction have hugely increased our knowledge of the disorder.

Source: Current Psychiatry Reports

DOI: 10.1007/s11920-019-1091-3

Authors: Simona A. Stilo, Robin M. Murray

Institutions: King's College London, South London and Maudsley NHS Foundation Trust, National Institute for Health and Care Research

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,760