Socioeconomic Status and DNA Methylation from Birth Through Mid-Childhood: A Prospective Study in Project Viva
Year: 2019
Type: article
Study design: Observational Study
Abstract: Aim: We investigated associations of prenatal socioeconomic status (SES) with DNA methylation at birth, and to explore persistence of associations into early (∼3 years) and mid-childhood (∼7 years) among 609 mother–child pairs in a Boston-area prebirth cohort. Materials & methods: First, we created a prenatal SES index comprising individual- and neighborhood-level metrics and examined associations of low (lowest 10%) versus high (upper 90%) SES with genome-wide DNA methylation in cord blood via the Infinium HumanMethylation450 BeadChip. Next, we evaluated persistence of associations detected in cord blood with DNA methylation of the same CpG sites measured in peripheral leukocytes in early- and mid-childhood. Results & conclusion: Low prenatal SES was associated with methylation at CpG sites near ACSF3, TNRC6C-AS1, MTMR4 and LRRN4. The relationship with LRRN4 persisted into early childhood.
Source: Epigenomics
Institutions: Michigan State University, Colorado School of Public Health, University of Colorado Anschutz, University of California, Berkeley, Harvard University, Harvard Pilgrim Health Care, Brigham and Women's Hospital, University of Rochester Medicine, Golisano Children's Hospital, KU Leuven, Columbia University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods, Novel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood Obesity, Pre- and Peri-natal Predictors of Childhood Obesity, Early Life DNA Methylation and Childhood Allergic Disease, Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods, Environmental Agents as Modulators of Disease Processes, Prenatal environmental determinants of health in young adulthood: a lifecourse approach
OpenAlex ID: W2973066886