Work

New Bisoxazoline Ligands Enable Enantioselective Electrocatalytic Cyanofunctionalization of Vinylarenes

Year: 2019

Type: article

Abstract: In contrast to the rapid growth of synthetic electrochemistry in recent years, enantioselective catalytic methods powered by electricity remain rare. In this work, we report the development of a highly enantioselective method for the electrochemical cyanophosphinoylation of vinylarenes. A new family of serine-derived chiral bisoxazolines with ancillary coordination sites were identified as optimal ligands.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.9b03296

Authors: Niankai Fu, Lu Song, Jinjian Liu, Yifan Shen, Juno C. Siu, Song Lin

Institution: Cornell University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Cornell University, National Institute of General Medical Sciences

Award: G4580980826