The Alzheimer's Disease Exposome
Year: 2019
Type: article
Abstract: INTRODUCTION: Environmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants. RESULTS AND DISCUSSION: We propose the "AD exposome" to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions.
Source: Alzheimer s & Dementia
Authors: Caleb E. Finch, Alexander M. Kulminski
Institutions: University of Southern California, Duke University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1583036818, G2540487512, G2777672791, G3579417275, G3599065402, G5550572583, G638371729, G641642826, Alzheimer Disease Research Center, G7154549238, ApoE2 and protective molecular signatures in Alzheimer's disease and aging, G7818745750, G8354128469, G8555804459, Relationships among Genetic Regulators of Aging Health and Lifespan, G966147650
OpenAlex ID: W2973204012