Work

Primal health research in the age of epigenetic clocks

Year: 2019

Type: article

Abstract: In the field of developmental origins of health and diseases among humans, classical epidemiology has limited power. We hypothesize that widely available "biological clocks" would introduce a new era in the history of health research. By contrasting chronological age and physiological age, "biological clocks" might become instrumental, without any delay, in exploring the possible long-term effects of a highly modified lifestyle during the "primal period". The aging process, life expectancy and health in general would be the main criteria. Today "DNA methylation GrimAge", based on estimations of plasma protein levels, may be considered to be the best predictor of lifespan and healthspan.

Source: Medical Hypotheses

DOI: 10.1016/j.mehy.2019.109403

Authors: Sylvie Odent, Michel Odent

Institutions: Centre National de la Recherche Scientifique, Institut de génétique et de développement de Rennes, Centre Hospitalier Universitaire de Rennes, Université de Rennes

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,850