Work

Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Year: 2019

Type: article

Abstract: While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

Source: Nanoscale

DOI: 10.1039/c9nr05794c

Authors: Elena A. Rozhkova, Byeongdu Lee, Judy A. Prasad, Yuzi Liu, Elena V. Shevchenko

Institutions: Argonne National Laboratory, Center for Nanoscale Materials, University of Chicago

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Energy, Office of Science, Basic Energy Sciences