Work

Formal Aniline Synthesis from Phenols through Deoxygenative N‐Centered Radical Substitution

Year: 2019

Type: article

Abstract: Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.201904288

Authors: Samuel W. Lardy, Kristine C. Luong, Valerie A. Schmidt

Institution: University of California San Diego

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: University of California, San Diego

OpenAlex ID: W2973972242

FWCI: 0.98

Cites: 80

Cited by: 20

Related to: 10