Work

Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)

Year: 2019

Type: article

Abstract: In article number 1902686, Jie Wang, Fengmin Lu, and co-workers indicate the potential of exosomes as a safe and effective delivery vehicle of functional gRNA and Cas9 protein, and the exosomes-mediated delivery of gene editing activity to adjacent and distant cells or tissues, which may further complicate the off-target and safety concerns of the CRISPR/Cas9 system.

Source: Small

DOI: 10.1002/smll.201970205

Authors: Ran Chen, Hongxin Huang, Hui Liu, Jingyuan Xi, Jing Ning, Wanjia Zeng, Congle Shen, Ting Zhang, Guangxin Yu, Qiang Xu, Xiangmei Chen, Jie Wang, Fengmin Lu

Institutions: Peking University, State Key Laboratory of Natural and Biomimetic Drugs

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2973982295

FWCI: 0.501

Cites:

Cited by: 10

Related to: 10