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Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Year: 2019

Type: article

Abstract: Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [13]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [28]. [3H]TRH (human, mouse, rat) is able to label both TRH1 and TRH2 receptors with Kd values of 13 and 9 nM respectively. Synthesis and biology of ring-modified L-Histidine containing TRH analogues has been reported [22].

Source: IUPHAR/BPS Guide to Pharmacology CITE

DOI: 10.2218/gtopdb/f63/2019.4

Authors: Anthony P. Davenport, Marvin Gershengorn, Rebecca Hills

Institutions: University of Cambridge, National Institutes of Health, University of Edinburgh

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W2974684444

FWCI:

Cites: 34

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Related to: 10