Work

New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

Year: 2019

Type: review

Abstract: Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer's disease (AD) and Parkinson's disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Source: International Journal of Environmental Research and Public Health

DOI: 10.3390/ijerph16193546

Authors: Airton Cunha Martins, Patricia Morcillo, Omamuyovwi Meashack Ijomone, Vivek Venkataramani, Fiona Edith Harrison, Eunsook Lee, Aaron Blaine Bowman, Michael Aschner

Institutions: Albert Einstein College of Medicine, Federal University of Technology, Universitätsmedizin Göttingen, Vanderbilt University Medical Center, Florida Agricultural and Mechanical University, Purdue University West Lafayette

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,824

Funders: National Institute of Environmental Health Sciences, National Institute on Minority Health and Health Disparities

Awards: Mechanism of manganese-induced impairment of astrocytic glutamate transporters, Gene-Neurotoxicant Interactions in Huntington Disease, Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain, FAMU RCMI Pharmaceutical Research Center, FAMU Center for Health Disparities Research, Mechanisms of Methylmercury Induced Neuronal Toxicity, Mechanisms of Manganese Neurotoxicity

OpenAlex ID: W2974766967

FWCI: 1.014

Cites: 158

Cited by: 100

Related to: 10