Year: 2019
Type: article
Abstract: was a physician whose first work was clinical in nature.One of Dahl's earliest studies involving the association of salt (NaCl) and hypertension was conducted using groups of employees at Brookhaven National Laboratory in Long Island, NY.This work demonstrated that for employees classified on the basis of a survey of eating habits as low, intermediate, or high salt intake, the percentage of individuals with hypertension in each group was positively correlated with salt intake (15).A more dramatic correlation between actual average daily NaCl intake and the percentage of individuals with hypertension in five geographically defined populations from around the world [Inuit (termed "Eskimos" in the original publication) (Alaska), Marshall Islanders (Pacific), Americans (Northern United States), Japanese (Southern Japan), and Japanese (Northern Japan)] was reported by Dahl in 1960 (7, 8).[Note that reference (8) is a reprint from the original symposium.]These data produced the well-known graph showing a linear relationship between dietary salt and percentage of individuals with hypertension (7, 8).Armed with this epidemiological evidence and the wide variation in BP response of Sprague-Dawley rats to salt (47), Dahl began to selectively breed outbred Sprague-Dawley rats for their BP when fed a high-salt (8% NaCl) diet.After only three generations of selective breeding, there was a clear separation into two lines, one line selected for high BP (S rats) and one line selected for low BP [salt-resistant (R) rats] (10, 11).In the initial breeding experiment, brother-sister mating
Authors: John P. Rapp, Michael R. Garrett
Language: English
Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2975601983