Work

Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes

Year: 2019

Type: article

Abstract: We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.

Source: Chemical Communications

DOI: 10.1039/c9cc04751d

Authors: Kanchan Basnet, Tayebeh Fatemipouya, Anna St. Lorenz, Mindy Nguyen, Oleh Taratula, Maged Henary, Kathryn B. Grant

Institutions: Georgia State University, Oregon State University

Language: English

Topic: Photochemistry and Electron Transfer Studies

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Georgia Research Alliance, Atlanta Clinical and Translational Science Institute, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor., Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia

OpenAlex ID: W2975697787

FWCI: 1.155

Cites: 37

Cited by: 14

Related to: 10