Year: 2019
Type: article
Abstract: C hanges in tumor size remain the standard metric for as- sessing response to cancer therapy, but such changes occur slowly and may fail to capture effects of molecularly targeted drugs.Since malignant cells commonly increase glycolytic metabolism, imaging reductions in glycolysis can shorten the timescale between starting therapy and determining success or failure of treatment.Fluorine 18 ( 18 F) fluorodeoxyglucose (FDG) PET, which quantifies intracellular transport and phosphorylation of the glucose analog 18 F FDG, is the standard imaging method for cancer metabolism.However, treatment frequently causes a paradoxical early increase in signal, the "flare effect", which delays reliable measurements of response to treatment.Hyperpolarization markedly increases signal from molecules labeled with carbon 13 ( 13 C),
Source: Radiology Imaging Cancer
Authors: Alyssa C. Cutter, Gary D. Luker
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W2975713878