Regulation of Cell Division in Bacteria by Monitoring Genome Integrity and DNA Replication Status
Year: 2019
Type: review
Abstract: and that most bacteria enforce the DNA damage checkpoint by expressing a small integral membrane protein. Resumption of cell division is then mediated by membrane-bound proteases that cleave the cell division inhibitor. Further, many bacterial cells have mechanisms to inhibit cell division that are regulated independently from the canonical LexA-mediated SOS response. In this review, we discuss several pathways used by bacteria to prevent cell division from occurring when genome instability is detected or before the chromosome has been fully replicated and segregated.
Source: Journal of Bacteriology
DOI: 10.1128/jb.00408-19
Authors: Peter E. Burby, Lyle A. Simmons
Institution: University of Michigan
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2976200218