Work

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Year: 2019

Type: article

Abstract: Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2019.05.006

Authors: Shohei Ikeda, Risa Mukai, Wataru Mizushima, Peiyong Zhai, Shin-ichi Oka, Michinari Nakamura, Dominic P. Del Re, Sebastiano Sciarretta, Chiao-Po Hsu, Hiroaki Shimokawa, Junichi Sadoshima

Institutions: Tohoku University, Rutgers New Jersey Medical School, Istituto Neurologico Mediterraneo, Sapienza University of Rome, Taipei Veterans General Hospital, National Yang Ming University

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400

Funders: Fondation Leducq, Japan Heart Foundation, U.S. Public Health Service, Bayer Yakuhin, Japan Society for the Promotion of Science, National Institute on Aging, National Heart, Lung, and Blood Institute

Awards: G1070754419, G1093645049, Regulation of myocardial growth and death by GSK-3, G3405322071, G4101633970, G4277395787, G4815079267, G5103921932, G5268010244, G5806494660, G5925465205, G647370962, G76062032, G8430394541, The investigation of the role of YAP in heart failure

OpenAlex ID: W2976353936

FWCI: 2.496

Cites: 22

Cited by: 44

Related to: 10