Year: 2019
Type: article
Abstract: Sweat-based analytics have recently caught the attention of researchers and medical professionals alike because they do not require professionally trained personnel or invasive collection techniques to obtain a sample.The following presents a small form-factor biosensor for reporting physiological ranges of cortisol present in ambient sweat (8-151 ng/ml).This device obtains cortisol measurements through low volumes of unstimulated sweat from the user's wrist.We designed a potentiostatic circuit on a printed circuit board to perform electrochemical testing techniques.The detection modality developed for quantifying sensor response to varying cortisol concentrations is a current based electrochemical technique, chronoamperometry (CA).From the results, the sensor can detect cortisol in the physiologically relevant ranges of cortisol; thus, the sensor is a noninvasive, label free, cost-effective solution for tracking cortisol levels for circadian diagnostics.Lay abstract: Cortisol, typically referred to as the 'stress hormone', plays a large role in typical body function.Cortisol matches the human sleep cycle, provides alertness, and is excreted by the adrenal cortex.The adrenal cortex is responsible for some of the body's hormonal secretions and can malfunction or fail with age or due to an autoimmune disorder.Our group has developed a wrist worn biosensor to monitor cortisol noninvasively with low volumes of sweat.The required sample is of low volume that no exercise or physical exertion is required for collection.The device allows researchers and users alike to determine cortisol concentration and thus monitor adrenal gland functionality.
Source: Future Science OA
Institution: The University of Texas at Dallas
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,165
OpenAlex ID: W2976547375