Work

Curcumin inhibits human non-small cell lung cancer xenografts by targeting STAT3 pathway.

Year: 2017

Type: article

Abstract: assays, curcumin significantly inhibited cell migration and tube formation of NCI-H460 cells, but transfection with pMXs-Stat3C, a dominant active mutant, could abolish the inhibitory effects of curcumin on the cells, suggesting curcumin inhibited tumor angiogenesis of NCI-H460 cells through the inactivation of STAT3. All data showed that curcumin could be a potential drug targeting STAT3 to treat NSCLC.

Source: PubMed

Authors: Xiaofang Xu, Yuping Zhu

Institution: Zhejiang Cancer Hospital

Language: English

Topic: Curcumin's Biomedical Applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2976715283

FWCI: 2.253

Cites: 38

Cited by: 44

Related to: 10