Work

The involvement and possible mechanism of NR4A1 in chondrocyte apoptosis during osteoarthritis.

Year: 2017

Type: article

Abstract: < 0.01). NR4A1 was located in nuclei of normal cartilage chondrocytes, but was translocated to mitochondria and co-located with B-cell lymphoma 2 in OA chondrocytes. NR4A1 expression in cultured chondrocytes could be promoted by both IL6 and TNF treatment. si-NR4A1 partly reduced TNF-induced cell apoptosis. Inhibiting p38 by SB203580 could decrease TNF-induced NR4A1 to some extent, while inhibiting JNK could not. So NR4A1 is likely to facilitate OA chondrocyte apoptosis, which is associated with p38 MAPK and mitochondrial apoptosis pathway. This study provides a potential therapeutic target for OA treatment and offers information for regulatory mechanisms in OA.

Source: Europe PMC (PubMed Central)

Authors: Xinge Shi, Hui Ye, Xuedong Yao, Yanzheng Gao

Institutions: Henan Provincial People's Hospital, Fujian Medical University, Third Affiliated Hospital of Southern Medical University, Second Affiliated Hospital of Fujian Medical University

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2976814768

FWCI: 2.39

Cites: 35

Cited by: 26

Related to: 10