Work

Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains.

Year: 2017

Type: article

Abstract: substrate of macroautophagy, in the brain was significantly decreased by the MLN4924 treatment. Our data suggest that systemic inhibition of neddylation by a 3-day MLN4924 treatment regime does not suppress macroautophagy activities in the heart and brain.

Source: PubMed Central

Authors: Casey A Reihe, Nickolas Pekas, Penglong Wu, Xuejun Wang

Institutions: University of South Dakota, Guangzhou Medical University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: PKG and PKA Duo-Activation to Treat Cardiac Proteotoxicity, The NRF2-p62 Axis in the Cross-Talk between Proteasomal and Lysosomal Degradation, The COP9 Signalosome in the Heart