Work

Going fast and getting lost : gene duplication in yeast

Year: 2007

Type: dissertation

Abstract: In this thesis I study how duplicate gene pairs created by a whole-genome duplication in an\nancestor of several yeast species were resolved. I show that gene duplication may lead not\njust to the emergence of new gene functions, but also to the emergence of new species. I\nused comparative genomics between ten hemiascomycete yeasts to study both the process\nof gene loss that caused over 4000 genes to be rapidly lost from the S. cerevisiae genome\nand the altered molecular evolution of those genes that have been retained in duplicate.\nAmong the genomes I studied was that of the non-model hemiascomycete yeast\nKluyveromyces polysporus, which was sequenced, annotated and analyzed during the\ncourse of this thesis.

Source: Arrow@dit (Dublin Institute of Technology)

Author: Devin R. Scannell

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2977360631

Cites: 265

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Related to: 10