Year: 2019
Type: review
Abstract: Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.
DOI: 10.3390/ijms20194945
Institutions: University of Coimbra, Biomedical Research Networking Center on Neurodegenerative Diseases, Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona, Universitat de Barcelona, Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria, University of Naples Federico II, Hospital de São João, University of Minho
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,824
OpenAlex ID: W2977488780