Work

Association of Two Methylenetetrahydrofolate Reductase Polymorphisms (rs1801133, rs1801131) with the Risk of Type 2 Diabetes in South-East of Iran.

Year: 2019

Type: article

Abstract: BACKGROUND: , and T2D in an Iranian population. METHODS: tests. RESULTS: The rs1801131 A/C polymorphism significantly increased the risk of T2D in codominant heterozygous AC (P=0.008), homozygous CC (P=0.01), and recessive CC (P=0.001) genotypes. Significant correlations were found regarding rs1801133 T/C gene polymorphism and the risk of T2D in codominant heterozygous TC (P=0.001), homozygote CC (P=0.001), and recessive CC (P=0.0001) models. The presence of the C allele is a potential risk factor for T2D for rs1801133 T/C (P=0.001) and rs1801131 A/C (P=0.04) polymorphisms. CONCLUSION: polymorphisms significantly increased the risk of T2D in our population. Further studies in other ethnicities are necessary to verify our findings.

Source: PubMed

Authors: Maryam Poodineh, Ramin Saravani, Mahboubeh Mirhosseini, Saman Sargazi

Institutions: Payame Noor University, Zahedan University of Medical Sciences

Language: English

Topic: Folate and B Vitamins Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2977608777

FWCI: 2.619

Cites: 29

Cited by: 19

Related to: 10