Work

Reply to Gleicher and Barad: Noninvasive preimplantation genetic testing may provide the solution to the problem of embryo mosaicism

Year: 2019

Type: letter

Abstract: We thank Drs. Gleicher and Barad for their interest in our recent paper, in which we report a higher reliability of noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) in spent medium compared with conventional trophectoderm (TE) biopsy (1). However, we respectfully disagree with their comments. The main points raised by Gleicher and Barad are that PGT-A, whether invasive or not, is not a useful test for ploidy because correction of chromosomal errors occurs downstream of blastocyst formation, and that this accounts for the high incidence of false positives associated with TE biopsy (2). We disagree that “self-correction” largely explains the high false-positive rate with the TE biopsy … [↵][1]1To whom correspondence may be addressed. Email: sunneyxie{at}pku.edu.cn. [1]: #xref-corresp-1-1

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1912042116

Authors: Lei Huang, Sijia Lu, Catherine Racowsky, X. Sunney Xie

Institutions: Brigham and Women's Hospital, Harvard University, Peking University

Language: English

Topic: Prenatal Screening and Diagnostics

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2977810860

Cites: 11

Cited by: 3

Related to: 10