Work

Recent insights into natural product inhibitors of matrix metalloproteinases

Year: 2019

Type: article

Abstract: Members of the matrix metalloproteinase (MMP) family have biological functions that are central to human health and disease, and MMP inhibitors have been investigated for the treatment of cardiovascular disease, cancer and neurodegenerative disorders. The outcomes of initial clinical trials with the first generation of MMP inhibitors proved disappointing. However, our growing understanding of the complexities of the MMP function in disease, and an increased understanding of MMP protein architecture and control of activity now provide new opportunities and avenues to develop MMP-focused therapies. Natural products that affect MMP activities have been of strong interest as templates for drug discovery, and for their use as chemical tools to help delineate the roles of MMPs that still remain to be defined. Herein, we highlight the most recent discoveries of structurally diverse natural product inhibitors to these proteases.

Source: MedChemComm

DOI: 10.1039/c9md00165d

Authors: Geetha B. Kumar, Bipin G. Nair, J. Jefferson P. Perry, David B. C. Martin

Institutions: Amrita Vishwa Vidyapeetham, University of California, Riverside, University of Iowa

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cancer Research Coordinating Committee, University of California, Riverside