Work

Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester

Year: 2019

Type: article

Source: Chemical Research in Toxicology

DOI: 10.1021/acs.chemrestox.9b00226

Authors: Jackie Shang, Richard Tschirret-Guth, Mark Cancilla, Koppara Samuel, Qing Chen, Harry R. Chobanian, Ann Thomas, Wei Tong, Hubert Josien, Alexei V. Buevich, Kaushik Mitra

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: Merck

OpenAlex ID: W2978932793

FWCI: 3.264

Cites: 41

Cited by: 19

Related to: 10