Immunoglobulin E induces colon cancer cell apoptosis via enhancing cyp27b1 expression.
Year: 2016
Type: article
Abstract: The pathogenesis of colon cancer (Cca) is to be further investigated. Vitamin D deficiency is associated with cancer growth; the underlying mechanism is unclear. Published data indicate that Cca cells express CD23. This study tests a hypothesis that exposure to IgE induces Cca cell apoptosis. In this study, the effect of ligation of CD23 by IgE on the expression of cyp27b1 was performed with Cca cells. The induction of apoptosis of Cca cells by IgE was assessed in a cell culture model. We observed that Cca cells express CD23; ligation of CD23 with IgE on Cca cells increased the expression of cyp27b1 in Cca, which promoted the conversion of VD3 to calcitriol, the latter increased the expression of FasL by Cca cells, and induced apoptosis of Cca cells. In conclusion, IgE is capable of inducing the cancer cell apoptosis via ligating CD23 and converting VD3 to calcitriol. The results suggest that IgE may have therapeutic potential in the treatment of Cca.
Source: PubMed
Authors: Zhen-Shi Ye, Li-Na Fan, Lin Wang, Bin Yang, Li-Feng Wang, Yuan-Sheng Liu, Su-Na Ji, Hong-Zhi Xu, Chuan-Xing Xiao
Institutions: Xiamen University, Zhongshan Hospital of Xiamen University
Language: English
Topic: Vitamin D Research Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2979358556