Work

Aging and the Krüppel-like factors.

Year: 2017

Type: article

Abstract: The mammalian Krüppel-like factors (KLFs) are a family of zinc-finger containing transcription factors with diverse patterns of expression and a wide array of cellular functions. While their roles in mammalian physiology are well known, there is a growing appreciation for their roles in modulating the fundamental progression of aging. Here we review the current knowledge of Krüppel-like factors with a focus on their roles in processes regulating aging and age-associated diseases.

Source: PubMed

Authors: Paishiun N Hsieh, David R Sweet, Liyan Fan, Mukesh K Jain

Institutions: University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, Case Western Reserve University

Language: English

Topic: Kruppel-like factors research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences