Work

On-demand radiosynthesis of N -succinimidyl-4-[ 18 F]fluorobenzoate ([ 18 F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18 F-labeling of protein

Year: 2019

Type: article

Abstract: F]SFB-PSCA diabody conjugate showed specific uptake in the PSCA-positive human prostate cancer xenograft. The successful development of a compact footprint of the EWOD radiosynthesizer has the potential to empower biologists to produce PET probes of interest themselves in a standard laboratory.

Source: RSC Advances

DOI: 10.1039/c9ra06158d

Authors: Hee-Kwon Kim, Muhammad Rashed Javed, Supin Chen, Kirstin A. Zettlitz, Jeffrey Collins, Anna M. Wu, Chang-Jin “C. J.” Kim, R. Michael van Dam, Pei Yuin Keng

Institutions: University of California, Los Angeles, Jeonbuk National University Hospital, Jeonbuk National University, University of Wah, National Tsing Hua University, City Of Hope National Medical Center, City of Hope, Beckman Research Institute

Language: English

Topic: Electrowetting and Microfluidic Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: David Geffen School of Medicine, University of California, Los Angeles

OpenAlex ID: W2979605075

FWCI: 0.539

Cites: 41

Cited by: 16

Related to: 10