Year: 2018
Type: article
Abstract: Introduction: Adequate pain control is often challenging, especially in patients with chronic pain, despite the availability of many medications and interventional techniques.Pain diagnosis is mainly based on the differentiation between nociceptive and neuropathic pain but, while for neuropathic pain the literature offers pharmacological algorithms, for nociceptive pain the pharmacological treatment recommendations are often based only on intensity or etiological diagnosis.The purpose of this study is to identify the factors contributing to pain generation in order to target pharmacological, interventional and rehabilitation treatments.Areas Covered: Literature was searched on the peculiarity of nociception of different tissues, pathogenetic mechanisms modifying pain perception, stimuli evoking pain in physiological and pathological conditions.A search was made also for possible treatment options targeting the different factors. Expert Opinion:We consider, in pain diagnosis, the different factors contributing to pain generation in order to guide the treatment algorithm.We analyze tissue specificity for chemical and physical stresses potentially causing pain, the changes that intervene in the peripheral and central pain pathways during disease, the stimuli that, acting on a pathological pain pathway, can trigger pain.The pain generating factors should be diagnosed and addressed with pharmacological, rehabilitation and interventional techniques.
Source: Journal of Surgery
Authors: Laura Demartini, Linda Bonezzi, Cesare Bonezzi
Institutions: Istituti Clinici Scientifici Maugeri, University of Genoa
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4235607295