Work

Autophagic degradation of FOXO3a represses the expression of PUMA to block cell apoptosis in cisplatin-resistant osteosarcoma cells.

Year: 2017

Type: article

Abstract: . In conclusion, our results provide new insights into the molecular link between autophagy and apoptosis that involves a FOXO3a-mediated transcriptional mechanism. Importantly, our results may facilitate the development of therapeutic strategies for osteosarcoma patients who have become resistant to cisplatin therapy.

Source: PubMed Central

Authors: Kaibiao Jiang, Caiguo Zhang, Bo Yu, Bin Chen, Zude Liu, Canglong Hou, Fei Wang, Hongxing Shen, Zhi Chen

Institutions: Shanghai Jiao Tong University, Renji Hospital, University of Colorado Anschutz, Second Military Medical University, Changhai Hospital

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2979782441

FWCI: 2.679

Cites: 34

Cited by: 48

Related to: 10