Work

Tailoring chemoenzymatic oxidation via in situ peracids

Year: 2019

Type: article

Abstract: Epoxidation chemistry often suffers from the challenging handling of peracids and thus requires in situ preparation. Here, we describe a two-phase enzymatic system that allows the effective generation of peracids and directly translate their activity to the epoxidation of olefins. We demonstrate the approach by application to lipid and olefin epoxidation as well as sulfide oxidation. These methods offer useful applications to synthetic modifications and scalable green processes.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c9ob01814j

Authors: Rebecca N. Re, Johanna C. Proessdorf, James J. La Clair, Maeva Subileau, Michael D. Burkart

Institutions: University of California San Diego, Ingénierie des Agropolymères et Technologies Emergentes

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green