Work

Sensing of citrulline modifications in histone peptides by deep cavitand hosts

Year: 2019

Type: article

Abstract: Arrayed cavitand:fluorophore sensor complexes can selectively sense small citrulline modifications at arginine residues on post-translationally modified peptides. The sensor can differentiate between different numbers of citrulline modifications, and a simple two-fluorophore, 6-component array can effect cross-reactive discrimination between single modifications in aqueous solution.

Source: Chemical Communications

DOI: 10.1039/c9cc07002h

Authors: Adam D. Gill, Briana L. Hickey, Siwen Wang, Min Xue, Wenwan Zhong, Richard J. Hooley

Institution: University of California, Riverside

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Chemistry

Awards: G1834929316, Developing lipopolysaccharide-neutralizing peptides through modular high throughput screening strategies, G7569915738, G8743719045